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Title: Transition metal-catalyzed synthesis of novel biologically relevant tryptophan analogues
Author(s): Esseveldt, B.C.J. van; Delft, F.L. van ; Smits, J.M.M.; Gelder, R. de ; Schoemaker, H.E.; Rutjes, F.P.J.T.
Publication year: 2004
Source: Advanced Synthesis & Catalysis, vol. 346, iss. 7, (2004), pp. 823-834
ISSN: 1615-4150
DOI: https://doi.org/10.1002/adsc.200404012
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/59211   https://hdl.handle.net/2066/59211

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Subject: Molecular Materials
Synthetic Organic Chemistry
Organization: Synthetic Organic Chemistry
Solid State Chemistry
Journal title:
Advanced Synthesis & Catalysis
Volume: vol. 346
Issue: iss. 7
Page start: p. 823
Page end: p. 834
Abstract:
A synthetic approach to the synthesis of novel tryptophan derivatives and benzofuran-containing amino acids is detailed. The sequence starts from enzymatically resolved enantiopure acetylene-containing amino acids, of which the acetylene function can be efficiently transformed into the targeted 2-substited indole and benzofuran moieties via Sonogashira-type coupling and metal-catalyzed cyclization.

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