Subject:
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Molecular Materials Synthetic Organic Chemistry |
Organization:
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Synthetic Organic Chemistry Solid State Chemistry |
Journal title:
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Advanced Synthesis & Catalysis
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Abstract:
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A synthetic approach to the synthesis of novel tryptophan derivatives and benzofuran-containing amino acids is detailed. The sequence starts from enzymatically resolved enantiopure acetylene-containing amino acids, of which the acetylene function can be efficiently transformed into the targeted 2-substited indole and benzofuran moieties via Sonogashira-type coupling and metal-catalyzed cyclization.
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