[Repetitive transcranial magnetic stimulation in depression; stimulation of the brain in order to cure the psyche]
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Publication year
2004Source
Nederlands Tijdschrift voor Geneeskunde, 148, 9, (2004), pp. 410-5ISSN
Publication type
Article / Letter to editor
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Organization
Neurology
Psychiatry
Journal title
Nederlands Tijdschrift voor Geneeskunde
Volume
vol. 148
Issue
iss. 9
Page start
p. 410
Page end
p. 5
Subject
EBP 1: Determinants in Health and Disease; UMCN 3.2: Cognitive neurosciencesAbstract
Transcranial magnetic stimulation (TMS) is a non-invasive approach to briefly stimulate or inhibit cortical brain areas. A novel approach entails the delivery of repetitive TMS pulses (rTMS) at a fixed frequency. In rTMS cortical activity is altered beyond the period of actual stimulation. The changes occur locally as well as at a distance in functionally connected brain areas. These features render rTMS a suitable tool to study normal brain functions and the pathophysiology of brain diseases. Furthermore, it is expected that rTMS could be used as a novel therapy for neurological or psychiatric diseases characterised by abnormal cortical activation. This possibility has been studied mostly in patients suffering from depression, where rTMS has been used to restore normal activity in the hypoactive prefrontal cortex. Despite statistically significant therapeutic effects in small sized trials, the clinical implications are still limited.
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- Electronic publications [122508]
- Faculty of Medical Sciences [90358]
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