Publication year
2004Source
Mini Reviews in Medicinal Chemistry, 4, 8, (2004), pp. 847-57ISSN
Publication type
Article / Letter to editor
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Organization
Gastroenterology
Journal title
Mini Reviews in Medicinal Chemistry
Volume
vol. 4
Issue
iss. 8
Page start
p. 847
Page end
p. 57
Subject
UMCN 5.1: Genetic defects of metabolismAbstract
From a nutritional standpoint, saturated triglycerides with a medium (6 to 12) carbon chain length (MCT) have traditionally been regarded as biologically inert substances, merely serving as a source of fuel calories that is relatively easily accessible for metabolic breakdown compared with long chain triglycerides (LCT). This quality of MCT has been shown to offer both benefits and risks depending on the clinical situation, with potential positive effects on protein metabolism in some studies on one side, and an increased risk for ketogenesis and metabolic acidosis on the other. At another level, studies regarding lipid effects of MCT on the immune system, as with LCT, so far have yielded equivocal results, although there is a recent experimental evidence to suggest that MCT possess immune modulating properties and should in fact be regarded as bioactive mediators. Most of this information comes from studies where effects of MCT have been compared with those of LCT in lipid emulsions, as part of parenteral (intravenous) nutrition formulations. Unfortunately, the relevance of these observations for clinical practice remains largely unclear because adequately powered trials that clearly point out the position of MCT in relation to structurally different lipids have not been performed. In the present paper we review the experimental and clinical evidence for cellular and physiological effects of nutritional MCT. In addition, studies describing possible mechanisms behind the observed effects of MCT will be discussed.
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- Academic publications [245103]
- Faculty of Medical Sciences [93207]
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