Epigenetic regulation of tumor suppressors in t(8:21)-containing AML.
SourceAnnals of Hematology, 83, 6, (2004), pp. 329-330
Article / Letter to editor
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Annals of Hematology
SubjectUMCN 1.2: Molecular diagnosis, prognosis and monitoring
The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.
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