Giant chalazia in the hyperimmunoglobulinemia E (hyper-IgE) syndrome.
SourceEuropean Journal of Ophthalmology, 14, 3, (2004), pp. 258-60
Article / Letter to editor
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European Journal of Ophthalmology
SubjectEBP 3: Effective Primary Care and Public Health; UMCN 3.3: Neurosensory disorders; UMCN 4.1: Microbial pathogenesis and host defense
PURPOSE: To report the occurrence of recurrent multiple giant chalazia in the hyperimmunoglobulin E syndrome (hyper-IgE syndrome or Job syndrome). METHODS: Two patients with hyperimmunoglobulinemia E (>500 IU/ml) had ophthalmologic examination and surgical treatment for chalazia of the eyelids. RESULTS: The hyper-IgE syndrome is a rare immunodeficiency and multisystem disorder characterized by recurrent skin and pulmonary abscesses, connective tissue abnormalities, and elevated levels of serum IgE. In two patients with the hyper-IgE syndrome, multiple giant chalazia were seen in upper and lower eyelids. Despite surgical incision new giant chalazia arose. CONCLUSIONS: Recurrent multiple giant chalazia may occur as an ophthalmic feature of the hyper-IgE syndrome.
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