Relationships between sex hormones assessed in amniotic fluid, and maternal and umbilical cord serum: what is the best source of information to investigate the effects of fetal hormonal exposure?
Fulltext:
57709.pdf
Embargo:
until further notice
Size:
116.3Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2004Source
Hormones and Behavior, 46, 5, (2004), pp. 663-9ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Psychiatry
Journal title
Hormones and Behavior
Volume
vol. 46
Issue
iss. 5
Page start
p. 663
Page end
p. 9
Subject
EBP 1: Determinants in Health and Disease; UMCN 3.2: Cognitive neurosciencesAbstract
Levels of testosterone (T) (total and free), androstenedione (A4), dehydroepiandrosterone sulphate (DHEAS), sex hormone-binding globulin (SHBG), and estradiol (E2) were measured by radioimmunoassay (RIA) in 156 normal pregnancies (77 male and 79 female fetuses). Samples were obtained from amniotic fluid, 2nd and 3rd trimester maternal serum, and umbilical cord serum at birth. During the critical period of brain differentiation, at the beginning of the second trimester of pregnancy, sex differences in T and A4 were found in amniotic fluid and not in maternal serum. This finding adds to the fact that mostly low and nonsignificant correlations were found for the different androgenic hormones between levels assessed in amniotic fluid and maternal plasma at this particular and very sensitive period of fetal brain development. On the other hand, high correlations were found for the same hormones between the samples of maternal serum in the 2nd and the 3rd trimester. Our data show that, of all available sources, amniotic fluid seems to be the best candidate to investigate the effects of early fetal androgen exposure.
This item appears in the following Collection(s)
- Academic publications [238430]
- Electronic publications [122512]
- Faculty of Medical Sciences [90359]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.