Mandibular reconstruction: a histological and histomorphometric study on the use of autogenous scaffolds, particulate cortico-cancellous bone grafts and platelet rich plasma in goats.

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Publication year
2004Source
International Journal of Oral and Maxillofacial Surgery, 33, 1, (2004), pp. 48-55ISSN
Publication type
Article / Letter to editor

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Organization
Oral and Maxillofacial Surgery
Periodontology and Biomaterials
Journal title
International Journal of Oral and Maxillofacial Surgery
Volume
vol. 33
Issue
iss. 1
Page start
p. 48
Page end
p. 55
Subject
UMCN 4.3: Tissue engineering and reconstructive surgeryAbstract
Twenty-eight goats underwent a continuity resection of the mandibular angle. In all goats primary reconstruction was carried out using specially designed pre-shaped osteosynthesis plates and monocortical screws. The original cortical scaffold was used to bridge the defect, filled with an autogenous particulate bone graft in 14 goats, whereas platelet-rich-plasma (PRP) was added in another 14 goats. Both groups were divided in three subgroups that were sacrificed after 3, 6 and 12 weeks. Histological and histomorphometric evaluation revealed that the use of PRP enhanced the bone healing considerably. This effect was statistically significant and particularly visible in the 6 and 12 weeks' groups
This item appears in the following Collection(s)
- Academic publications [202563]
- Electronic publications [100732]
- Faculty of Medical Sciences [79925]
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