The right hippocampus participates in short-term memory maintenance of object-location associations
Publication year
2006Number of pages
9 p.
Source
NeuroImage, 33, 1, (2006), pp. 374-382ISSN
Publication type
Article / Letter to editor
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Organization
SW OZ DCC NRP
SW OZ DCC CO
Donders Centre for Cognitive Neuroimaging
PI Group Memory & Emotion
Former Organization
SW OZ NICI BI
SW OZ NICI CO
F.C. Donders Centre for Cognitive Neuroimaging
Journal title
NeuroImage
Volume
vol. 33
Issue
iss. 1
Languages used
English (eng)
Page start
p. 374
Page end
p. 382
Subject
130 000 Cognitive Neurology & Memory; Cognitive neuroscienceAbstract
Doubts have been cast on the strict dissociation between short- and long-term memory systems. Specifically, several neuroimaging studies have shown that the medial temporal lobe, a region almost invariably associated with long-term memory, is involved in active short-term memory maintenance. Furthermore, a recent study in hippocampally lesioned patients has shown that the hippocampus is critically involved in associating objects and their locations, even when the delay period lasts only 8 s. However, the critical feature that causes the medial temporal lobe, and in particular the hippocampus, to participate in active maintenance is still unknown. This study was designed in order to explore hippocampal involvement in active maintenance of spatial and non-spatial associations. Eighteen participants performed a delayed-match-to-sample task in which they had to maintain either object–location associations, color–number association, single colors, or single locations. Whole-brain activity was measured using event-related functional magnetic resonance imaging and analyzed using a random effects model. Right lateralized hippocampal activity was evident when participants had to maintain object–location associations, but not when they had to maintain object–color associations or single items. The present results suggest a hippocampal involvement in active maintenance when feature combinations that include spatial information have to be maintained online.
This item appears in the following Collection(s)
- Academic publications [245263]
- Donders Centre for Cognitive Neuroimaging [4022]
- Electronic publications [132514]
- Faculty of Social Sciences [30345]
- Open Access publications [106120]
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