The effects of vigabatrin on spike and wave discharges in WAG-Rij rats
until further notice
Number of pages
SourceEpilepsy Research, 76, 1, (2007), pp. 34-40
Article / Letter to editor
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SW OZ DCC SMN
SW OZ DCC BO
SW OZ NICI BI
F.C. Donders Centre for Cognitive Neuroimaging
SW OZ NICI KI
SubjectBiological psychology; DI-BCB_DCC_Theme 3: Plasticity and Memory; Biologische psychologie
The effects of vigabatrin, which increases GABA concentrations by inhibiting GABA transaminase, on spike and wave discharges (SWDs) in the electroencephalogram of WAG/Rij rats were studied. Vigabatrin increased the incidence and duration of the SWDs, suggesting a quantitative GABA(A)ergic involvement in the mechanism(s) underlying the starting and stopping of an ongoing SWD. Also, vigabatrin decreased the SWD peak frequency, suggesting an important role of GABA(B) in the mechanism(s) underlying the peak frequency of the SWDs. Vigabatrin gradually changed the course of the hazard rates of the SWD durations, suggesting a quatitative GABAergic role in the mechanism(s) underlying the stopping of an ongoing SWD.
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