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Publication year
2007Source
Scandinavian Journal of Work, Environment & Health, 33, 1, (2007), pp. 13-28ISSN
Publication type
Article / Letter to editor

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Organization
Health Evidence
Gynaecology
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Scandinavian Journal of Work, Environment & Health
Volume
vol. 33
Issue
iss. 1
Page start
p. 13
Page end
p. 28
Subject
IGMD 3: Genomic disorders and inherited multi-system disorders; NCEBP 12: Human Reproduction; UMCN 5.2: Endocrinology and reproductionAbstract
Several studies have shown a decline in human semen quality and increased risks of male subfertility. This paper provides an overview of the mechanisms of pesticide-induced reproductive toxicity and the effects on male fertility since exposure to pesticides may be one of the causes of these disorders. Pesticides may directly damage spermatozoa, alter Sertoli cell or Leydig cell function, or disrupt the endocrine function in any stage of hormonal regulation (hormone synthesis, release, storage, transport, and clearance; receptor recognition and binding; thyroid function; and the central nervous system). These mechanisms are described with respect to the effects of pesticide exposure in vitro and in vivo. In epidemiologic studies, effects on sperm quality and time to pregnancy are reviewed. Clear effects on male fertility have been demonstrated for some pesticides [eg, dibromochloropropane, ethylene dibromide]. But results from more recent studies are inconsistent, and no uniform conclusion can be drawn about the effects of pesticides on male reproduction.
This item appears in the following Collection(s)
- Academic publications [202802]
- Electronic publications [100870]
- Faculty of Medical Sciences [80020]
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