Biological activity of tri-calciumphosphate/hydroxyl-apatite granules mixed with impacted morsellized bone graft. A study in rabbits.

Fulltext:
52780.pdf
Embargo:
until further notice
Size:
517.0Kb
Format:
PDF
Description:
publisher's version
Publication year
2007Source
Journal of Biomedical Materials Research Part B-Applied Biomaterials, 81, 2, (2007), pp. 476-485ISSN
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
Orthopaedics
Journal title
Journal of Biomedical Materials Research Part B-Applied Biomaterials
Volume
vol. 81
Issue
iss. 2
Page start
p. 476
Page end
p. 485
Subject
NCEBP 10: Human Movement & Fatigue; NCMLS 3: Tissue engineering and pathology; UMCN 4.3: Tissue engineering and reconstructive surgery; NCEBP 10: Human Movement & FatigueAbstract
Reconstruction of bone defects with impacted morsellized cancellous bone grafts (MCB) is a popular method. Because of a shortage of human bone, mixing with biomaterials may be attractive. Ceramics may be used as bone graft extenders. In this study, various volume mixtures of biphasic tri-calciumphosphate/hydroxyl-apatite (TCP-HA) granules (1.5-2 mm) with MCB were examined in a non-loaded defect model in rabbits. Direct post-operatively, many 10-150 microm TCP-HA particles were present due to impaction. Irrespective to the group, after 8 weeks, virtually all MCB was resorbed and most TCP-HA granules were osseous-integrated with newly formed bone. The cross-sectional areas of TCP-HA after 8 weeks was generally smaller compared with direct post-operatively and the number of small 10-150 microm TCP-HA particles seemed reduced. Macrophages and giant cells were sparse after 8 weeks. In conclusion, the osteoconductivity of various mixtures of MCB and TCP-HA granules is not dependent on the ratio of TCP-HA over MCB. The reduced number of the 10-150microm TCP-HA particles after 8 weeks, may suggest that a cellular mediated resorption process of TCP-HA granules took place. Based on these favorable biological findings subsequent in-vivo experiments are warranted in load-bearing conditions to investigate whether these findings hold for joint reconstruction purposes.
This item appears in the following Collection(s)
- Academic publications [205116]
- Electronic publications [103350]
- Faculty of Medical Sciences [81054]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.