Ultrasound-guided transrectal implantation of gold markers for prostate localization during external beam radiotherapy: complication rate and risk factors.
until further notice
SourceInternational Journal of Radiation Oncology, Biology, Physics, 69, 3, (2007), pp. 671-676
Article / Letter to editor
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Epidemiology, Biostatistics & HTA
International Journal of Radiation Oncology, Biology, Physics
SubjectNCEBP 1: Molecular epidemiology; ONCOL 1: Hereditary cancer and cancer-related syndromes; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection; UMCN 1.1: Functional Imaging; UMCN 1.2: Molecular diagnosis, prognosis and monitoring
PURPOSE: To report the complication rate and risk factors of transrectally implanted gold markers, used for prostate position verification and correction procedures. METHODS AND MATERIALS: In 209 consecutive men with localized prostate cancer, four gold markers (1 x 7 mm) were inserted under ultrasound guidance in an outpatient setting, and the toxicity was analyzed. All patients received a questionnaire regarding complications after marker implantation. The complications and risk factors were further evaluated by reviewing the medical charts. RESULTS: Of the 209 men, 13 (6.2%) had a moderate complication, consisting of pain and fever that resolved after treatment with oral medication. In 1.9% of the men, minor voiding complaints were observed. Other minor transient complications, defined as hematuria lasting >3 days, hematospermia, and rectal bleeding, occurred in 3.8%, 18.5%, and 9.1% of the patients, respectively. These complications were seen more often in patients with advanced tumor stage, younger age, and shorter duration of hormonal therapy. CONCLUSION: Transrectal gold marker implantation for high-precision prostate radiotherapy is a safe and well-tolerated procedure.
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