The predictive value of vitamin B12 concentrations and hyperhomocysteinaemia for cardiovascular disease.

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Publication year
2007Source
Netherlands Heart Journal, 15, 9, (2007), pp. 291-294ISSN
Publication type
Article / Letter to editor

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Organization
Gastroenterology
Cardiology
Journal title
Netherlands Heart Journal
Volume
vol. 15
Issue
iss. 9
Page start
p. 291
Page end
p. 294
Subject
IGMD 2: Molecular gastro-enterology and hepatology; NCEBP 14: Cardiovascular diseases; UMCN 2.1: Heart, lung and circulation; UMCN 5.1: Genetic defects of metabolismAbstract
BACKGROUND: Cardiovascular disease has been associated with both homocysteine and vitamin B12 levels. However, little information is available about the mutual relation in cardiovascular patients. The aim of this study was to assess the prevalence of vitamin B12 deficiency in patients with cardiovascular disease, and to study the correlation with homocysteine levels. METHODS: Blood samples were taken from 229 patients who had been admitted to the Coronary Care Unit of the Heart-Lung Centre of the Radboud University Medical Centre in Nijmegen, the Netherlands. Patient demographics and clinical characteristics were assessed from medical files. Adjusted logistic regression was used to study the associations between vitamin B12, homocysteine and ischaemic heart disease. RESULTS: In 70 patients (33%) serum vitamin B12 levels were below the lower limit of normal (<203 ng/l). Sixty-nine patients (33%) had vitamin B12 concentrations in the lower normal range (between 203 and 339 ng/l). Plasma homocysteine levels above the upper limit of normal were found in 83 out of the 229 patients (36%). Adjusted odds ratios for both vitamin B12 (0.76, 95% CI 0.44-1.30) and homocysteine (1.27, 95% CI 0.74-2.18) levels did not show a statistical association with ischaemic heart disease. No association was found between serum vitamin B12 levels and plasma homocysteine. CONCLUSION: Our data suggest that hyperhomocysteinaemia and low serum vitamin B12 concentrations are independent and cannot be used as a diagnostic tool for ischaemic heart disease. (Neth Heart J 2007;15:291-4.).
This item appears in the following Collection(s)
- Academic publications [204968]
- Electronic publications [103219]
- Faculty of Medical Sciences [81049]
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