Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene.
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Publication year
2007Source
Cancer Genetics and Cytogenetics, 179, 1, (2007), pp. 11-8ISSN
Publication type
Article / Letter to editor
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Organization
Human Genetics
Paediatrics - OUD tm 2017
Journal title
Cancer Genetics and Cytogenetics
Volume
vol. 179
Issue
iss. 1
Page start
p. 11
Page end
p. 8
Subject
NCEBP 1: Molecular epidemiology; NCMLS 6: Genetics and epigenetic pathways of disease; ONCOL 1: Hereditary cancer and cancer-related syndromes; ONCOL 3: Translational research; UMCN 1.2: Molecular diagnosis, prognosis and monitoringAbstract
Our group and others had previously developed a high throughput procedure to map translocation breakpoints using chromosome flow sorting in conjunction with microarray-based comparative genomic hybridization (arrayCGH). Here we applied both conventional positional cloning and integrated arrayCGH procedures to the mapping of constitutional chromosome anomalies in four patients with renal cell cancer (RCC), three with a chromosome 3 translocation, and one with an insertion involving chromosome 3. In one of these patients, who was carrying a t(3;4)(p13;p15), the KCNIP4 gene was found to be disrupted. KCNIP4 belongs to a family of potassium channel-interacting proteins and is highly expressed in normal kidney cells. In addition, KCNIP4 splice variants have specifically been encountered in RCC.
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- Electronic publications [132838]
- Faculty of Medical Sciences [93207]
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