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Title: Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
Author(s): Gudmundsson, J.; Sulem, P.; Steinthorsdottir, V.; Bergthorsson, J.T.; Thorleifsson, G.; Manolescu, A.; Rafnar, T.; Gudbjartsson, D.F.; Agnarsson, B.A.; Baker, A.; Sigurdsson, A.; Benediktsdottir, K.R.; Jakobsdottir, M.; Blondal, T.; Stacey, S.N.; Helgason, A.; Gunnarsdottir, S.; Olafsdottir, A.; Kristinsson, K.T.; Birgisdottir, B.; Ghosh, S.; Thorlacius, S.; Magnusdottir, D.; Stefansdottir, G.; Kristjansson, K.; Bagger, Y.; Wilensky, R.L.; Reilly, M.P.; Morris, A.D.; Kimber, C.H.; Adeyemo, A.; Chen, Y.; Zhou, J. ; So, W.Y.; Tong, P.C.; Ng, M.C.; Hansen, T.; Andersen, G.; Borch-Johnsen, K.; Jorgensen, T.; Tres, A.; Fuertes, F.; Ruiz-Echarri, M.; Asin, L.; Saez, B.; Boven, E. van; Klaver, S.; Swinkels, D.W. ; Aben, K.K.H. ; Graif, T.; Cashy, J.; Suarez, B.K.; Vierssen Trip, O. van; Frigge, M.L.; Ober, C.; Hofker, M.H.; Wijmenga, C.; Christiansen, C.; Rader, D.J.; Palmer, C.N.; Rotimi, C.; Chan, J.C.; Pedersen, O.; Sigurdsson, G.; Benediktsson, R.; Jonsson, E.; Einarsson, G.V.; Mayordomo, J.I.; Catalona, W.J.; Kiemeney, L.A.L.M. ; Barkardottir, R.B.; Gulcher, J.R.; Thorsteinsdottir, U.; Kong, A.; Stefansson, K.
Publication year: 2007
Source: Nature Genetics, vol. 39, iss. 8, (2007), pp. 977-983
ISSN: 1061-4036
DOI: https://doi.org/10.1038/ng2062
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/52115   https://hdl.handle.net/2066/52115

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Subject: IGMD 7: Iron metabolism
N4i 1: Pathogenesis and modulation of inflammation
NCEBP 1: Molecular epidemiology
ONCOL 1: Hereditary cancer and cancer-related syndromes
ONCOL 3: Translational research
ONCOL 5: Aetiology, screening and detection
UMCN 1.1: Functional Imaging
UMCN 1.2: Molecular diagnosis, prognosis and monitoring
UMCN 1.5: Interventional oncology
Organization: Dentistry
Clinical Chemistry
Health Evidence
Urology
Former Organization: Epidemiology, Biostatistics & HTA
Journal title:
Nature Genetics
Volume: vol. 39
Issue: iss. 8
Page start: p. 977
Page end: p. 983
Abstract:
We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.

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