Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting.
until further notice
SourceNature Reviews. Immunology, 7, 10, (2007), pp. 790-802
Article / Letter to editor
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Nature Reviews. Immunology
SubjectNCMLS 1: Immunity, infection and tissue repair; NCMLS 2: Immune Regulation; NCMLS 3: Tissue engineering and pathology; ONCOL 3: Translational research; UMCN 1.4: Immunotherapy, gene therapy and transplantation; UMCN 4.3: Tissue engineering and reconstructive surgery
The realization that dendritic cells (DCs) orchestrate innate and adaptive immune responses has stimulated research on harnessing DCs to create more effective vaccines. Early clinical trials exploring autologous DCs that were loaded with antigens ex vivo to induce T-cell responses have provided proof of principle. Here, we discuss how direct targeting of antigens to DC surface receptors in vivo might replace laborious and expensive ex vivo culturing, and facilitate large-scale application of DC-based vaccination therapies.
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