Diagnostic accuracy of the clapping test in Parkinsonian disorders.
until further notice
SourceJournal of Neurology, 254, 10, (2007), pp. 1366-1369
Article / Letter to editor
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Donders Centre for Cognitive Neuroimaging
Epidemiology, Biostatistics & HTA
Journal of Neurology
SubjectDCN 1: Perception and Action; DCN 2: Functional Neurogenomics; DCN 3: Neuroinformatics; NCEBP 10: Human Movement & Fatigue; NCEBP 11: Alzheimer Centre; NCEBP 14: Cardiovascular diseases; NCEBP 2: Evaluation of complex medical interventions; UMCN 1.5: Interventional oncology; UMCN 3.2: Cognitive neurosciences; UMCN 5.1: Genetic defects of metabolism; NCEBP 10: Human Movement & Fatigue
BACKGROUND : To determine the diagnostic value of the clapping test, which has been proposed as a reliable measure to differentiate between progressive supranuclear palsy (where performance is impaired) and Parkinson's disease (where performance should be normal). METHODS : Our study group included a large cohort of consecutive outpatients including 44 patients with Parkinson's disease, 48 patients with various forms of atypical parkinsonism and 149 control subjects. All subjects performed the clapping test according to a standardized protocol. RESULTS : Clapping test performance was normal in all control subjects, and impaired in 63% of the patients with atypical parkinsonism. Unexpectedly, we also found an impaired clapping test in 29% of the patients with Parkinson's disease. CONCLUSION : Although the proportion with an abnormal clapping test was significantly higher in atypical parkinsonism, the clapping test did not discriminate well between Parkinson's disease and atypical parkinsonism.
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