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Title: Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: a Dutch case-control study.
Author(s): Donk, M. van den; Visker, M.H.P.W.; Harryvan, J.L.; Kok, F.J.; Kampman, E.
Publication year: 2007
Source: Cancer Letters, vol. 250, iss. 1, (2007), pp. 146-153
ISSN: 0304-3835
DOI: https://doi.org/10.1016/j.canlet.2006.10.002
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/51760   http://hdl.handle.net/2066/51760

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Subject: From Natural Philosophy to Science
NCEBP 1: Molecular epidemiology
ONCOL 1: Hereditary cancer and cancer-related syndromes
ONCOL 3: Translational research
ONCOL 5: Aetiology, screening and detection
UMCN 1.5: Interventional oncology
Organization: Health Evidence
Former Organization: Epidemiology, Biostatistics & HTA
Journal title:
Cancer Letters
Volume: vol. 250
Issue: iss. 1
Page start: p. 146
Page end: p. 153
Abstract:
Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.

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