Title alternative:
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Risico van acute leverinsufficiëntie bij kinderen door chronische accidentele overdosering van paracetamol
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Subject:
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IGMD 3: Genomic disorders and inherited multi-system disorders IGMD 8: Mitochondrial medicine NCEBP 2: Evaluation of complex medical interventions NCMLS 4: Energy and redox metabolism UMCN 2.2: Vascular medicine and diabetes UMCN 5.1: Genetic defects of metabolism UMCN 5.4: Renal disorders |
Organization:
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Paediatrics Internal Medicine Pharmacology-Toxicology |
Journal title:
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Nederlands Tijdschrift voor Geneeskunde
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Abstract:
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Two girls aged 4 and 3 years, respectively, experienced acute liver failure due to accidental ingestion of supratherapeutic doses of paracetamol (90 mg/kg/day or more). Recognition of chronic paracetamol intoxication as a cause of acute hepatic failure is often delayed. It is important to consider the possibility of paracetamol-induced hepatotoxicity because many patients will recover if treated with N-acetylcysteine, as did both of these children. Patients with acute liver failure due to chronic paracetamol intoxication present with very high transaminase levels (> 4000 U/l), disproportionately low total bilirubin levels (< 200 micromol/l) and often hypoglycaemia.
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