[Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)]

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Publication year
2007Source
Nederlands Tijdschrift voor Geneeskunde, 151, 16, (2007), pp. 897-900ISSN
Publication type
Article / Letter to editor

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Organization
Paediatrics - OUD tm 2017
Internal Medicine
Pharmacology-Toxicology
Former Organization
Pharmacology/Toxicology
Journal title
Nederlands Tijdschrift voor Geneeskunde
Volume
vol. 151
Issue
iss. 16
Page start
p. 897
Page end
p. 900
Subject
IGMD 3: Genomic disorders and inherited multi-system disorders; IGMD 8: Mitochondrial medicine; NCEBP 2: Evaluation of complex medical interventions; NCMLS 4: Energy and redox metabolism; UMCN 2.2: Vascular medicine and diabetes; UMCN 5.1: Genetic defects of metabolism; UMCN 5.4: Renal disordersAbstract
Two girls aged 4 and 3 years, respectively, experienced acute liver failure due to accidental ingestion of supratherapeutic doses of paracetamol (90 mg/kg/day or more). Recognition of chronic paracetamol intoxication as a cause of acute hepatic failure is often delayed. It is important to consider the possibility of paracetamol-induced hepatotoxicity because many patients will recover if treated with N-acetylcysteine, as did both of these children. Patients with acute liver failure due to chronic paracetamol intoxication present with very high transaminase levels (> 4000 U/l), disproportionately low total bilirubin levels (< 200 micromol/l) and often hypoglycaemia.
This item appears in the following Collection(s)
- Academic publications [227248]
- Electronic publications [108532]
- Faculty of Medical Sciences [86732]
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