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Publication year
2007Source
Trends in Cell Biology, 17, 4, (2007), pp. 178-186ISSN
Publication type
Article / Letter to editor

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Organization
Tumorimmunology
Paediatrics - OUD tm 2017
Journal title
Trends in Cell Biology
Volume
vol. 17
Issue
iss. 4
Page start
p. 178
Page end
p. 186
Subject
NCMLS 1: Immunity, infection and tissue repair; NCMLS 2: Immune Regulation; ONCOL 2: Age-related aspects of cancer; ONCOL 3: Translational research; UMCN 1.4: Immunotherapy, gene therapy and transplantationAbstract
Adherent cells respond to mechanical properties of the surrounding extracellular matrix. Mechanical forces, sensed at specialized cell-matrix adhesion sites, promote actomyosin-based contraction within the cell. By manipulating matrix rigidity and adhesion strength, new roles for actomyosin contractility in the regulation of basic cellular functions, including cell proliferation, migration and stem cell differentiation, have recently been discovered. These investigations demonstrate that a balance of forces between cell adhesion on the outside and myosin II-based contractility on the inside of the cell controls many aspects of cell behavior. Disturbing this balance contributes to the pathogenesis of various human diseases. Therefore, elaborate signaling networks have evolved that modulate myosin II activity to maintain tensional homeostasis. These include signaling pathways that regulate myosin light chain phosphorylation as well as myosin II heavy chain interactions.
This item appears in the following Collection(s)
- Academic publications [204980]
- Electronic publications [103240]
- Faculty of Medical Sciences [81051]
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