Writer's cramp: restoration of striatal D2-binding after successful biofeedback-based sensorimotor training.
until further notice
SourceParkinsonism & Related Disorders, 13, 3, (2007), pp. 170-173
Article / Letter to editor
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Medical Physics and Biophysics
Parkinsonism & Related Disorders
SubjectDCN 2: Functional Neurogenomics; EBP 1: Determinants of Health and Disease; N4i 1: Pathogenesis and modulation of inflammation; NCEBP 8: Psychological determinants of chronic illness; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection; UMCN 3.2: Cognitive neurosciences; EBP 1: Determinants of Health and Disease
INTRODUCTION: Previous studies of writer's cramp have detected cerebral sensorimotor abnormalities in this disorder and, more specifically, a reduced striatal D2-binding as assessed by [(123)I]IBZM SPECT. However, empirical data were lacking about the influence of effective biofeedback-based sensorimotor training on D2 receptor binding. METHODS: To determine whether there is a restoration of D2-binding after successful sensorimotor treatment, pre- and posttreatment SPECTs were compared in five patients with writer's cramp and correlated with improvement in handwriting. RESULTS: After treatment, the clinical and electromyographic picture appeared substantially improved connected with a significant increase in D2-binding to nearly normal levels similar to normative data in age/sex-matched healthy subjects. CONCLUSION: The current study supported the view that writer's cramp results from a plastic adaptation of a rectifiable nigrostriatal dopaminergic system and that effective sensorimotor training leads to increased efficacy of striatal dopaminergic transmission.
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