Neuromuscular abnormalities in ataxia telangiectasia: a clinical, electrophysiological and muscle ultrasound study.
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SourceNeuropediatrics, 38, 3, (2007), pp. 117-121
Article / Letter to editor
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Paediatrics - OUD tm 2017
SubjectDCN 1: Perception and Action; DCN 2: Functional Neurogenomics; N4i 1: Pathogenesis and modulation of inflammation; UMCN 2.1: Heart, lung and circulation; UMCN 3.1: Neuromuscular development and genetic disorders; UMCN 4.1: Microbial pathogenesis and host defense; UMCN 5.1: Genetic defects of metabolism
Thirteen classical ataxia telangiectasia (A-T) patients, varying in age from 1 to 25 years, were studied clinically, electrophysiologically as well as by muscle ultrasound to chart the development and spectrum of neuromuscular abnormalities in A-T. The most prominent finding was a progressive axonal sensorimotor polyneuropathy, apparent by electromyography and muscle ultrasound from the age of 8 years and becoming clinically discernible around 12 years of age. Before the age of 8 years decreased tendon reflexes and slightly slowed sensory nerve conduction velocities could already be observed. With routine electrophysiological techniques the severe polyneuropathy precludes conclusions about the presence of anterior horn cell loss in older patients.
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