IGF-1 CA repeat variant and breast cancer risk in postmenopausal women.
until further notice
SourceEuropean Journal of Cancer, 43, 11, (2007), pp. 1718-1722
Article / Letter to editor
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European Journal of Cancer
SubjectDCN 1: Perception and Action; DCN 2: Functional Neurogenomics; UMCN 1.2: Molecular diagnosis, prognosis and monitoring; UMCN 3.2: Cognitive neurosciences
IGF-I is an important growth factor for the mammary gland. We evaluated the relationship of the IGF-I CA(n) polymorphism with breast cancer risk in Caucasian postmenopausal women and performed a meta-analysis of published data. The IGF-I CA(n) polymorphism was genotyped in 4091 from the Rotterdam Study. A disease-free survival analysis was performed along with a meta-analysis of all available data on IGF-I CA(n) polymorphism and breast cancer risk. During follow-up 159 women were diagnosed with breast cancer. The disease-free survival analysis adjusted for age at entry, age at menopause, body mass index and waist hip ratio yielded a HR=0.97 (95% CI=0.59-1.58) for CA(19) non-carriers against carriers. The meta-analysis using the random-effects model gave a pooled OR of 1.26 (95% CI=0.95-1.82) for IGF-I CA(19) non-carriers versus CA(19) homozygous carriers. According to these results, the IGF-I CA(19) promoter polymorphism is not likely to predict the risk of breast cancer.
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