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Title: Tissue inhibitors of metalloproteinases (TIMPs): their biological functions and involvement in oral disease.
Author(s): Verstappen, J. ; Hoff, J.W. Von den
Publication year: 2006
Source: Journal of Dental Research, vol. 85, iss. 12, (2006), pp. 1074-1084
ISSN: 0022-0345
DOI: https://doi.org/10.1177/154405910608501202
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/51068   http://hdl.handle.net/2066/51068

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Subject: NCMLS 3: Tissue engineering and pathology
UMCN 4.3: Tissue engineering and reconstructive surgery
Organization: Orthodontics and Oral Biology
Journal title:
Journal of Dental Research
Volume: vol. 85
Issue: iss. 12
Page start: p. 1074
Page end: p. 1084
Abstract:
Several families of enzymes are responsible for the degradation of extracellular matrix (ECM) proteins during the remodeling of tissues. An important family of such enzymes is that of the matrix metalloproteinases (MMPs). To control MMP-mediated ECM breakdown, tissue inhibitors of metalloproteinases (TIMPs) are able to inhibit MMP activity. A disturbed balance of MMPs and TIMPs is found in various pathologic conditions, such as cancer, rheumatoid arthritis, and periodontitis. The role of MMPs in pathology has been extensively described in the literature. The main focus of this review lies in the biological functions of TIMPs and their occurrence in disease, especially in the head and neck area. Their biological functions and their role in diseases like oral cancers and periodontitis, and in the development of cleft palate, will be discussed. Finally, the diagnostic and therapeutical opportunities of TIMPs will be evaluated.

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