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Title: Chronic herpes simplex virus encephalitis in childhood.
Author(s): Leen, W.G. ; Weemaes, C.M.R. ; Verbeek, M.M. ; Willemsen, M.A.A.P. ; Rotteveel, J.J.
Publication year: 2006
Source: Pediatric Neurology, vol. 35, iss. 1, (2006), pp. 57-61
ISSN: 0887-8994
DOI: https://doi.org/10.1016/j.pediatrneurol.2005.12.015
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/50896   https://hdl.handle.net/2066/50896

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Subject: DCN 1: Perception and Action
DCN 2: Functional Neurogenomics
DCN 3: Neuroinformatics
N4i 1: Pathogenesis and modulation of inflammation
NCEBP 11: Alzheimer Centre
UMCN 3.1: Neuromuscular development and genetic disorders
UMCN 3.2: Cognitive neurosciences
Organization: Paediatrics
Neurology
Journal title:
Pediatric Neurology
Volume: vol. 35
Issue: iss. 1
Page start: p. 57
Page end: p. 61
Abstract:
Although herpes simplex virus is a major cause of acute encephalitis in childhood, chronic herpes simplex virus encephalitis has only rarely been reported. This report presents a case of chronic herpes simplex virus encephalitis in a 6-year-old female. Diagnosis was based on the detection of herpes simplex virus deoxyribonucleic acid by polymerase chain reaction in combination with the cerebrospinal fluid/serum ratio of herpes simplex virus-specific immunoglobulin G, the presence of herpes simplex virus-specific oligoclonal immunoglobulin G bands in cerebrospinal fluid, and calcifications in the temporal regions found on cerebral computed tomographic scan. Prolonged antiviral therapy was beneficial to later mental development.

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