Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma.
until further notice
SourceBritish Journal of Cancer, 95, 3, (2006), pp. 374-7
Article / Letter to editor
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Epidemiology, Biostatistics & HTA
Radboud University Nijmegen Medical Centre
British Journal of Cancer
SubjectEBP 1: Determinants in Health and Disease; NCEBP 1: Molecular epidemiology; NCMLS 3: Growth and differentiation; NCMLS 6: Genetics and epigenetic pathways of disease; ONCOL 1: Hereditary cancer and cancer-related syndromes; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection; UMCN 1.2: Molecular diagnosis, prognosis and monitoring; UMCN 1.5: Interventional oncology; UMCN 5.1: Genetic defects of metabolism
We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations.
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