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Title: Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma.
Author(s): Dijk, B.A.C. van ; Schouten, L.J.; Oosterwijk, E. ; Hulsbergen-van de Kaa, C.A. ; Kiemeney, L.A.L.M. ; Goldbohm, R.A. ; Schalken, J.A. ; Brandt, P.A. van den
Publication year: 2006
Source: British Journal of Cancer, vol. 95, iss. 3, (2006), pp. 374-377
ISSN: 0007-0920
DOI: http://dx.doi.org/10.1038/sj.bjc.6603281
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/50872   http://hdl.handle.net/2066/50872

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Subject: EBP 1: Determinants in Health and Disease
NCEBP 1: Molecular epidemiology
NCMLS 3: Growth and differentiation
NCMLS 6: Genetics and epigenetic pathways of disease
ONCOL 1: Hereditary cancer and cancer-related syndromes
ONCOL 3: Translational research
ONCOL 5: Aetiology, screening and detection
UMCN 1.2: Molecular diagnosis, prognosis and monitoring
UMCN 1.5: Interventional oncology
UMCN 5.1: Genetic defects of metabolism
NCMLS 3: Growth and differentiation
Organization: Clinical Chemistry
Health Evidence
Urology
Pathology
Former Organization: Epidemiology, Biostatistics & HTA
Radboud University Nijmegen Medical Centre
Journal title:
British Journal of Cancer
Volume: vol. 95
Issue: iss. 3
Page start: p. 374
Page end: p. 377
Abstract:
We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations.

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