An effective correlation dimension and burst suppression ratio of the EEG in rat. Correlation with sevoflurane induced anaesthetic depth.
Fulltext:
50614.pdf
Embargo:
until further notice
Size:
669.2Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2006Source
European Journal of Anaesthesiology, 23, 5, (2006), pp. 391-402ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
SW OZ DCC AI
SW OZ DCC SMN
Anesthesiology
Former Organization
SW OZ NICI KI
SW OZ NICI BI
Journal title
European Journal of Anaesthesiology
Volume
vol. 23
Issue
iss. 5
Page start
p. 391
Page end
p. 402
Subject
CTR 3: Translational research; DCN 1: Perception and Action; N4i 4: Auto-immunity, transplantation and immunotherapy; UMCN 3.2: Cognitive neurosciencesAbstract
BACKGROUND AND OBJECTIVE: Anaesthesiologists need parameters that measure the depth of anaesthesia. In the context of this need, the present study investigated in rats how two variables from the electroencephalogram, the burst suppression ratio and effective correlation dimension correlated with a measure of anaesthetic depth as measured in the strength of a noxious withdrawal reflex. METHODS: Eight rats were exposed to different inspiratory concentrations of sevoflurane, each rat in two separate experiments. In the first experiment, spontaneously breathing animals could move freely and no painful stimuli were applied. In the second experiment, in mechanically ventilated restrained anaesthetized rats, the withdrawal reflex was measured every 80 s. In both experiments the electroencephalogram was continuously recorded. The concentration in the effector compartment was estimated using a first order two compartment model. Correlation dimension was computed following the Grassberger/Procaccia/Takens approach with optimized parameter settings to achieve maximum sensitivity to anaesthetic drug effects and enable real-time computation. The Hill, equation was fitted to the data, describing the effect as a function of sevoflurane concentration. RESULTS: Good correlations of Depth of Anaesthesia with correlation dimension as well as burst suppression ratio were established in both types of experiments. Arousal by noxious stimuli decreased burst suppression ratio and increased correlation dimension. The effective sevoflurane concentration associated with 50% of the maximum effect (C50) was higher in experiment II (stimulation) than in experiment I (no stimulation): i.e. for correlation dimension 2.18% vs. 0.60% and for burst suppression ratio 3.07% vs. 1.73%. The slope factors were: gammaCD = 4.15 vs. gammaCD = 1.73 and gammaBSR = 5.2 vs. gammaBSR = 5.4. Correlation dimension and burst suppression ratio both correlated with the strength of the withdrawal reflex with correlation coefficients of 0.46 and 0.66 respectively (P < 0.001). CONCLUSIONS: Both correlation dimension and burst suppression ratio are related to anaesthetic depth and are affected by noxious stimuli. The relationship between anaesthetic depth and burst suppression ratio is confirmed and the potential of correlation dimension is demonstrated.
This item appears in the following Collection(s)
- Academic publications [246165]
- Electronic publications [133736]
- Faculty of Medical Sciences [93268]
- Faculty of Social Sciences [30430]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.