Comparison of image-derived and arterial input functions for estimating the rate of glucose metabolism in therapy-monitoring 18F-FDG PET studies.

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Publication year
2006Source
The Journal of Nuclear Medicine (1978), 47, 6, (2006), pp. 945-949ISSN
Publication type
Article / Letter to editor

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Organization
Nuclear Medicine
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
The Journal of Nuclear Medicine (1978)
Volume
vol. 47
Issue
iss. 6
Page start
p. 945
Page end
p. 949
Subject
EBP 2: Effective Hospital Care; N4i 1: Pathogenesis and modulation of inflammation; NCEBP 2: Evaluation of complex medical interventions; ONCOL 3: Translational research; ONCOL 4: Quality of Care; ONCOL 5: Aetiology, screening and detection; UMCN 1.1: Functional ImagingAbstract
The use of dynamic (18)F-FDG PET to determine changes in tumor metabolism requires tumor and plasma time-activity curves. Because arterial sampling is invasive and laborious, our aim was to validate noninvasive image-derived input functions (IDIFs). METHODS: We obtained 136 dynamic (18)F-FDG PET scans of 76 oncologic patients. IDIFs were determined using volumes of interest over the left ventricle, ascending aorta, and abdominal aorta. The tumor metabolic rate of glucose (MRGlu) was determined with the Patlak analysis, using arterial plasma time-activity curves and IDIFs. RESULTS: MRGlu using all 3 IDIFs showed a high correlation with MRGlu based on arterial sampling. Comparability between the measures was also high, with the intraclass correlation coefficient being 0.98 (95% confidence interval, 0.97-0.99) for the ascending aorta IDIF, 0.94 (0.92-0.96) for the left ventricle IDIF, and 0.96 (0.93-0.98) for the abdominal aorta IDIF. CONCLUSION: The use of IDIFs is accurate and simple and represents a clinically viable alternative to arterial blood sampling.
This item appears in the following Collection(s)
- Academic publications [205116]
- Electronic publications [103350]
- Faculty of Medical Sciences [81054]
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