Relation between muscle fiber conduction velocity and fiber size in neuromuscular disorders.
SourceJournal of Applied Physiology, 100, 6, (2006), pp. 1837-41
Article / Letter to editor
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Journal of Applied Physiology
SubjectDCN 1: Perception and Action; DCN 2: Functional Neurogenomics; NCEBP 10: Human Movement & Fatigue; NCMLS 3: Growth and differentiation; UMCN 3.1: Neuromuscular Development and genetic Disorders
To determine the relation between muscle fiber conduction velocity (MFCV) and muscle fiber diameter (MFD) in pathological conditions, we correlated invasively measured MFCV values with MFD data obtained from muscle needle biopsies in 96 patients with various neuromuscular disorders. MFCV was significantly correlated with MFD and independent of the underlying disorder. Pathological diameter changes were fiber-type dependent, with corresponding MFCVs. A linear equation expresses the relation well: MFCV (m/s)=0.043.MFD (microm)+0.83. We conclude that fiber diameter determines MFCV largely independent of the underlying neuromuscular disorders studied.
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