Cortical excitatory amino acid release and cell function during hypotension in near-term born lambs.

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Title:	Cortical excitatory amino acid release and cell function during hypotension in near-term born lambs.
Author(s):	Os, S.H.G. van; Ruitenbeek, W. ; Hopman, J.; Klaessens, J.H.G.M. ; Bor, M. van de
Publication year:	2006
Source:	Biology of the Neonate, vol. 90, iss. 2, (2006), pp. 128-134
ISSN:	0006-3126
DOI:	https://doi.org/10.1159/000092450
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/50415
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Subject:	IGMD 1: Functional imaging IGMD 3: Genomic disorders and inherited multi-system disorders UMCN 2.1: Heart, lung and circulation
Organization:	Paediatrics Medical Microbiology
Journal title:	Biology of the Neonate
Volume:	vol. 90
Issue:	iss. 2
Page start:	p. 128
Page end:	p. 134
Abstract:	BACKGROUND: Energy failure due to insufficient cerebral O2-supply leads to excess accumulation of calcium ions in presynaptic neurons, followed by excess release of excitatory amino acids, which are potent neurotoxins, into the synaptic cleft. AIM: To investigate whether electrocortical brain activity (ECBA) can provide an adequate measure for excitatory amino acid release due to hemorrhagic hypotension. METHODS: Ten near-term lambs were delivered at 127 days of gestation (term: 147 days). After a stabilization period, hypotension was induced by stepwise withdrawal of blood. Cerebral microdialysis was used to measure the concentrations of glutamate and aspartate. RESULTS: During hypotension, mean arterial blood pressure, cerebral O2-supply and ECBA decreased and the extracellular concentration of glutamate increased significantly. ECBA was significantly related to glutamate (R2: 0.67, p < 0.001) and aspartate (R2: 0.57, p < 0.001) concentrations. CONCLUSION: The extracellular release of glutamate and aspartate in the cerebral cortex increases after hemorrhagic hypotension in near-term born lambs. The extracellular overflow of glutamate and aspartate were significantly inversely related to ECBA.