until further notice
SourceNature Reviews. Neuroscience, 7, 9, (2006), pp. 724-31
Article / Letter to editor
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Paediatrics - OUD tm 2017
Epidemiology, Biostatistics & HTA
Nature Reviews. Neuroscience
SubjectEBP 1: Determinants in Health and Disease; IGMD 5: Health aging / healthy living; IGMD 6: Hormonal regulation; NCEBP 14: Cardiovascular diseases; NCEBP 1: Molecular epidemiology; NCMLS 4: Energy and redox metabolism; ONCOL 3: Translational research; UMCN 2.2: Vascular medicine and diabetes; UMCN 5.2: Endocrinology and reproduction
Neural tube closure takes place during early embryogenesis and requires interactions between genetic and environmental factors. Failure of neural tube closure is a common congenital malformation that results in morbidity and mortality. A major clinical achievement has been the use of periconceptional folic acid supplements, which prevents approximately 50-75% of cases of neural tube defects. However, the mechanism underlying the beneficial effects of folic acid is far from clear. Biochemical, genetic and epidemiological observations have led to the development of the methylation hypothesis, which suggests that folic acid prevents neural tube defects by stimulating cellular methylation reactions. Exploring the methylation hypothesis could direct us towards additional strategies to prevent neural tube defects.
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