Reproducibility of cerebral blood volume measurements by near infrared spectroscopy in 16 healthy elderly subjects.
Publication year
2006Source
Physiological Measurement, 27, 3, (2006), pp. 255-264ISSN
Publication type
Article / Letter to editor

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Organization
Geriatrics
Journal title
Physiological Measurement
Volume
vol. 27
Issue
iss. 3
Page start
p. 255
Page end
p. 264
Subject
DCN 1: Perception and Action; EBP 2: Effective Hospital Care; NCEBP 11: Alzheimer Centre; NCEBP 14: Cardiovascular diseases; UMCN 3.2: Cognitive neurosciencesAbstract
Near infrared spectroscopy (NIRS) is a non-invasive method to monitor cerebral haemodynamics. Used either alone or in combination with other non-invasive methods such as transcranial Doppler sonography, this technique is well suited for use in cerebrovascular research in ageing. Reproducibility of NIRS, however, has only been determined in neonates and adults. We applied controlled desaturation (the O(2)-method) to measure the cerebral blood volume (CBV) with NIRS in 16 healthy subjects aged 65 to 88. This method uses deoxygenated haemoglobin (the concentration of which is manipulated by desaturation) as an intravascular tracer for NIRS. We determined repeatability (between tests interval: 2 min), short-term reproducibility (intervals of 20 and 40 min) and long-term reproducibility (interval > 2 weeks). We found a coefficient of variation (CV) of 12.5% for repeatability and a CV of 11.7% for short-term reproducibility. The CV for long-term reproducibility was 15%. We conclude that NIRS can reproducibly measure CBV in subjects aged 65 and older, using the O(2)-method. In this group of healthy subjects, this method was well tolerated.
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- Academic publications [203856]
- Electronic publications [102285]
- Faculty of Medical Sciences [80326]
- Open Access publications [70942]
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