Representation of head-centric flow in the human motion complex.
Publication year
2006Source
The Journal of Neuroscience, 26, 21, (2006), pp. 5616-27ISSN
Publication type
Article / Letter to editor
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Organization
Cognitive Neuroscience
Former Organization
Medical Physics and Biophysics
Journal title
The Journal of Neuroscience
Volume
vol. 26
Issue
iss. 21
Page start
p. 5616
Page end
p. 27
Subject
DCN 1: Perception and Action; UMCN 3.2: Cognitive neurosciencesAbstract
Recent neuroimaging studies have identified putative homologs of macaque middle temporal area (area MT) and medial superior temporal area (area MST) in humans. Little is known about the integration of visual and nonvisual signals in human motion areas compared with monkeys. Through extra-retinal signals, the brain can factor out the components of visual flow on the retina that are induced by eye-in-head and head-in-space rotations and achieve a representation of flow relative to the head (head-centric flow) or body (body-centric flow). Here, we used functional magnetic resonance imaging to test whether extra-retinal eye-movement signals modulate responses to visual flow in the human MT+ complex. We distinguished between MT and MST and tested whether subdivisions of these areas may transform the retinal flow into head-centric flow. We report that interactions between eye-movement signals and visual flow are not evenly distributed across MT+. Pursuit hardly influenced the response of MT to flow, whereas the responses in MST to the same retinal stimuli were stronger during pursuit than during fixation. We also identified two subregions in which the flow-related responses were boosted significantly by pursuit, one overlapping part of MST. In addition, we found evidence of a metric relation between rotational flow relative to the head and fMRI signals in a subregion of MST. The latter findings provide an important advance over published single-cell recordings in monkey MST. A visual representation of the rotation of the head in the world derived from head-centric flow may supplement semicircular canals signals and is appropriate for cross-calibrating vestibular and visual signals.
This item appears in the following Collection(s)
- Academic publications [245050]
- Electronic publications [132309]
- Faculty of Medical Sciences [93209]
- Open Access publications [105918]
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