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Publication year
2006Source
Archives of Physical Medicine and Rehabilitation, 87, 5, (2006), pp. 688-96ISSN
Publication type
Article / Letter to editor
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Organization
Physiology
Nephrology
Radboudumc Extern
Journal title
Archives of Physical Medicine and Rehabilitation
Volume
vol. 87
Issue
iss. 5
Page start
p. 688
Page end
p. 96
Subject
IGMD 5: Health aging / healthy living; NCEBP 14: Cardiovascular diseases; UMCN 2.2: Vascular medicine and diabetesAbstract
OBJECTIVE: To assess the time course of adaptations in leg vascular dimension and function within the first 6 weeks after a spinal cord injury (SCI). DESIGN: Longitudinal study design. SETTING: University medical center and rehabilitation clinic. PARTICIPANTS: Six men were studied serially at 1, 2, 3, 4, and 6 weeks after SCI. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Diameter, blood flow, and shear rate levels of the common femoral artery (CFA), superficial femoral artery (SFA), brachial artery, and carotid artery were measured with echo Doppler ultrasound (diameter, blood flow, shear rate). Endothelial function in the SFA was measured with flow-mediated dilation (FMD). In addition, leg volume and blood pressure measurements were performed. RESULTS: Femoral artery diameter (CFA, 25%; SFA, 16%; P<.01) and leg volume (22%, P<.01) decreased simultaneously, and these reductions were largely accomplished within 3 weeks postinjury. Significant increases were observed for basal shear rate levels (64% increase at week 3; 117% increase at week 6; P<.01), absolute FMD responses (8% increase at week 3, 23% increase at week 6; P<.05) and relative FMD responses (26% increase at week 3, 44% increase at week 6; P<.001). CONCLUSIONS: Our findings show a rapid onset of adaptations in arterial dimension and function to extreme inactivity in humans. Vascular adaptations include extensive reductions in femoral diameter and leg volume, as well as increased basal shear rate levels and FMD responses, which all appear to be largely accomplished within 3 weeks after an SCI.
This item appears in the following Collection(s)
- Academic publications [245050]
- Electronic publications [132309]
- Faculty of Medical Sciences [93209]
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