Preoperative assessment of the circumferential margin in rectal cancer is more informative in treatment planning than the T stage.

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Publication year
2006Source
Techniques in Coloproctology, 10, 3, (2006), pp. 171-6ISSN
Publication type
Article / Letter to editor

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Organization
Pathology
Former Organization
Radboud University Nijmegen Medical Centre
Journal title
Techniques in Coloproctology
Volume
vol. 10
Issue
iss. 3
Page start
p. 171
Page end
p. 6
Subject
CTR 3: Translational research; ONCOL 1: Hereditary cancer and cancer-related syndromes; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection; UMCN 1.5: Interventional oncologyAbstract
Preventing local recurrence in rectal cancer means achieving a free circumferential resection margin (CRM) through an optimal combination of surgery, radiotherapy and chemotherapy. This requires a differentiation between primary resectable and locally advanced cancers. The T staging used, while being a powerful marker of prognosis, has two major downsides. First, accuracy of preoperative predictions of the T stage is unacceptably low. Second, a T3 tumor can be either primary resectable or locally advanced. A review of the literature was performed to establish the value of the CRM as the preferred preoperative staging classification, and to establish the feasibility of predicting the CRM using modern day, high-resolution imaging techniques. We advocate using the CRM as preoperative staging classification. Magnetic resonance imaging and multislice computed tomography offer an accurate pre-operative prediction of the CRM, and staging by means of predicted CRM offers the ideal combination of accuracy and clinical relevance.
This item appears in the following Collection(s)
- Academic publications [227437]
- Electronic publications [107154]
- Faculty of Medical Sciences [86157]
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