Subject:
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N4i 1: Pathogenesis and modulation of inflammation N4i 3: Poverty-related infectious diseases N4i 4: Auto-immunity, transplantation and immunotherapy NCMLS 1: Infection and autoimmunity UMCN 4.1: Microbial pathogenesis and host defense |
Journal title:
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FEMS Immunology and Medical Microbiology
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Abstract:
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The putative pneumococcal proteinase maturation protein A is a potential pneumococcal vaccine candidate. We examined serum antipneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal proteinase maturation protein A antibodies is associated with pneumococcal contacts. A higher antipneumococcal proteinase maturation protein A antibody concentration at 18 months of age tends to predict for a lower risk of pneumococcal acute otitis media in the following 6 months (relative risk: 0.84, 95% confidence interval: 0.62-1.13).
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