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Title: Development of antibodies against the putative proteinase maturation protein A in relation to pneumococcal carriage and otitis media.
Author(s): Bogaert, D.; Holmlund, E.; Lahdenkari, M.; Groot, R. de ; Kilpi, T.; Hermans, P.W.M. ; Kayhty, H.
Publication year: 2006
Source: FEMS Immunology and Medical Microbiology, vol. 46, iss. 2, (2006), pp. 166-168
ISSN: 0928-8244
DOI: http://dx.doi.org/10.1111/j.1574-695X.2005.00012.x
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/49984   http://hdl.handle.net/2066/49984

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Subject: N4i 1: Pathogenesis and modulation of inflammation
N4i 3: Poverty-related infectious diseases
N4i 4: Auto-immunity, transplantation and immunotherapy
NCMLS 1: Infection and autoimmunity
UMCN 4.1: Microbial pathogenesis and host defense
Organization: Paediatrics
Journal title:
FEMS Immunology and Medical Microbiology
Volume: vol. 46
Issue: iss. 2
Page start: p. 166
Page end: p. 168
Abstract:
The putative pneumococcal proteinase maturation protein A is a potential pneumococcal vaccine candidate. We examined serum antipneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal proteinase maturation protein A antibodies is associated with pneumococcal contacts. A higher antipneumococcal proteinase maturation protein A antibody concentration at 18 months of age tends to predict for a lower risk of pneumococcal acute otitis media in the following 6 months (relative risk: 0.84, 95% confidence interval: 0.62-1.13).

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