Carbogen breathing differentially enhances blood plasma volume and 5-fluorouracil uptake in two murine colon tumor models with a distinct vascular structure.
Publication year
2006Source
Neoplasia, 8, 6, (2006), pp. 477-487ISSN
Publication type
Article / Letter to editor

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Organization
Medical Oncology
Radiology
Radiation Oncology
Neurology
Journal title
Neoplasia
Volume
vol. 8
Issue
iss. 6
Page start
p. 477
Page end
p. 487
Subject
DCN 1: Perception and Action; DCN 2: Functional Neurogenomics; IGMD 8: Mitochondrial medicine; IGMD 9: Renal disorder; NCMLS 2: Immune Regulation; NCMLS 3: Growth and differentiation; NCMLS 4: Energy and redox metabolism; ONCOL 1: Hereditary cancer and cancer-related syndromes; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection; UMCN 1.1: Functional Imaging; UMCN 1.3: Tumor microenvironment; UMCN 3.1: Neuromuscular development and genetic disorders; NCMLS 3: Growth and differentiationAbstract
For the systemic treatment of colorectal cancer, 5-fluorouracil (FU)-based chemotherapy is the standard. However, only a subset of patients responds to chemotherapy. Breathing of carbogen (95% O2 and 5% CO2) may increase the uptake of FU through changes in tumor physiology. This study aims to monitor in animal models in vivo the effects of carbogen breathing on tumor blood plasma volume, pH, and energy status, and on FU uptake and metabolism in two colon tumor models C38 and C26a, which differ in their vascular structure and hypoxic status. Phosphorus-31 magnetic resonance spectroscopy (MRS) was used to assess tumor pH and energy status, and fluorine-19 MRS was used to follow FU uptake and metabolism. Advanced magnetic resonance imaging methods using ultrasmall particles of iron oxide were performed to assess blood plasma volume. The results showed that carbogen breathing significantly decreased extracellular pH and increased tumor blood plasma volume and FU uptake in tumors. These effects were most significant in the C38 tumor line, which has the largest relative vascular area. In the C26a tumor line, carbogen breathing increased tumor growth delay by FU. In this study, carbogen breathing also enhanced systemic toxicity by FU.
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- Academic publications [205104]
- Electronic publications [103316]
- Faculty of Medical Sciences [81055]
- Open Access publications [71820]
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