The effects of 6 months of increased water intake on blood sodium, glomerular filtration rate, blood pressure, and quality of life in elderly (aged 55-75) men.

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Title:	The effects of 6 months of increased water intake on blood sodium, glomerular filtration rate, blood pressure, and quality of life in elderly (aged 55-75) men.
Author(s):	Spigt, M.G.; Knottnerus, J.A.; Westerterp, K.R.; Olde Rikkert, M.G.M. ; Schayck, C.P. van
Publication year:	2006
Source:	Journal of the American Geriatrics Society, vol. 54, iss. 3, (2006), pp. 438-443
ISSN:	0002-8614
DOI:	https://doi.org/10.1111/j.1532-5415.2005.00606.x
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/49765
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Subject:	DCN 1: Perception and Action EBP 2: Effective Hospital Care IGMD 5: Health aging / healthy living NCEBP 11: Alzheimer Centre NCEBP 14: Cardiovascular diseases NCEBP 4: Quality of hospital and integrated care UMCN 3.2: Cognitive neurosciences
Organization:	Geriatrics General Practice
Journal title:	Journal of the American Geriatrics Society
Volume:	vol. 54
Issue:	iss. 3
Page start:	p. 438
Page end:	p. 443
Abstract:	OBJECTIVES: To study whether there are any negative or positive effects of 6 months of increased fluid intake in reasonably healthy elderly men. DESIGN: Randomized trial. SETTING: Community-based. PARTICIPANTS: One hundred forty-one healthy participants aged 55 to 75. INTERVENTION: One group was given the advice to increase their daily fluid intake by 1.5 L of water; the other group was given placebo medication (8 mL inactive syrup per day). MEASUREMENTS: At 6 months blood sodium, glomerular filtration rate (GFR), blood pressure, and quality of life (QOL) were measured. The changes in water turnover were measured using deuterium. RESULTS: Most subjects did not manage to increase their fluid intake by 1.5 L. The average increase in the intervention group was approximately 1 L. Twenty-four-hour water turnover in the water group was 359 mL (95% confidence interval=171-548) higher than that of the control group at 6-month follow-up. Blood pressure, sodium level, GFR, and QOL did not change significantly in either group during the intervention period. In addition, the cases reporting a worsening on the effect measures were equally distributed over the two study groups. CONCLUSION: The advice to increase fluid intake by 1.5 L had no negative effects in reasonably healthy men aged 55 to 75.