Nucleotide oligomerization domain 2 (Nod2) is not involved in the pattern recognition of Candida albicans.
SourceClinical and Vaccine Immunology, 13, 3, (2006), pp. 423-5
Article / Letter to editor
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Clinical and Vaccine Immunology
SubjectDCN 1: Perception and Action; DCN 2: Functional Neurogenomics; EBP 3: Effective Primary Care and Public Health; IGMD 3: Genomic disorders and inherited multi-system disorders; N4i 1: Pathogenesis and modulation of inflammation; N4i 2: Invasive mycoses and compromised host; NCMLS 1: Infection and autoimmunity; NCMLS 6: Genetics and epigenetic pathways of disease; UMCN 4.1: Microbial pathogenesis and host defense; UMCN 5.1: Genetic defects of metabolism
Nucleotide-binding oligomerization domain 2 (Nod2) pathways are known to interact with Toll-like receptor 2 (TLR2) and TLR4, which are pattern recognition receptors for Candida albicans. We observed that the prevalence of Nod2 polymorphisms was not increased in patients with Candida infections. Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans.
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