Subject:
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DCN 1: Perception and Action DCN 2: Functional Neurogenomics EBP 3: Effective Primary Care and Public Health IGMD 3: Genomic disorders and inherited multi-system disorders N4i 1: Pathogenesis and modulation of inflammation N4i 2: Invasive mycoses and compromised host NCMLS 1: Infection and autoimmunity NCMLS 6: Genetics and epigenetic pathways of disease UMCN 4.1: Microbial pathogenesis and host defense UMCN 5.1: Genetic defects of metabolism |
Organization:
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Internal Medicine Psychiatry |
Journal title:
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Clinical and Vaccine Immunology
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Abstract:
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Nucleotide-binding oligomerization domain 2 (Nod2) pathways are known to interact with Toll-like receptor 2 (TLR2) and TLR4, which are pattern recognition receptors for Candida albicans. We observed that the prevalence of Nod2 polymorphisms was not increased in patients with Candida infections. Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans.
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