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Title: Nucleotide oligomerization domain 2 (Nod2) is not involved in the pattern recognition of Candida albicans.
Author(s): Smits-van der Graaf, C.A.A. ; Netea, M.G. ; Franke, B. ; Girardin, S.E.; Meer, J.W.M. van der ; Kullberg, B.J.
Publication year: 2006
Source: Clinical and Vaccine Immunology, vol. 13, iss. 3, (2006), pp. 423-425
ISSN: 1556-6811
DOI: http://dx.doi.org/10.1128/CVI.13.3.423-425.2006
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/49534   http://hdl.handle.net/2066/49534

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Subject: DCN 1: Perception and Action
DCN 2: Functional Neurogenomics
EBP 3: Effective Primary Care and Public Health
IGMD 3: Genomic disorders and inherited multi-system disorders
N4i 1: Pathogenesis and modulation of inflammation
N4i 2: Invasive mycoses and compromised host
NCMLS 1: Infection and autoimmunity
NCMLS 6: Genetics and epigenetic pathways of disease
UMCN 4.1: Microbial pathogenesis and host defense
UMCN 5.1: Genetic defects of metabolism
Organization: Internal Medicine
Psychiatry
Journal title:
Clinical and Vaccine Immunology
Volume: vol. 13
Issue: iss. 3
Page start: p. 423
Page end: p. 425
Abstract:
Nucleotide-binding oligomerization domain 2 (Nod2) pathways are known to interact with Toll-like receptor 2 (TLR2) and TLR4, which are pattern recognition receptors for Candida albicans. We observed that the prevalence of Nod2 polymorphisms was not increased in patients with Candida infections. Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans.

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