Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study.

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Publication year
2006Author(s)
Source
Cancer Causes & Control, 17, 7, (2006), pp. 957-69ISSN
Publication type
Article / Letter to editor

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Organization
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Cancer Causes & Control
Volume
vol. 17
Issue
iss. 7
Page start
p. 957
Page end
p. 69
Subject
EBP 1: Determinants in Health and Disease; UMCN 1.5: Interventional oncologyAbstract
Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (<120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake.
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- Academic publications [227727]
- Electronic publications [107314]
- Faculty of Medical Sciences [86204]
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