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Publication year
2006Source
Drug Metabolism Reviews, 38, 3, (2006), pp. 477-514ISSN
Publication type
Article / Letter to editor

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Organization
Internal Medicine
Clinical Pharmacy
Journal title
Drug Metabolism Reviews
Volume
vol. 38
Issue
iss. 3
Page start
p. 477
Page end
p. 514
Subject
CTR 2: Clinical Pharmacology and physiology; EBP 3: Effective Primary Care and Public Health; EBP 4: Quality of Care; N4i 1: Pathogenesis and modulation of inflammation; N4i 2: Invasive mycoses and compromised host; N4i 3: Poverty-related infectious diseases; NCEBP 13: Infectious diseases and international health; NCEBP 3: Implementation Science; NCMLS 1: Infection and autoimmunity; UMCN 3.2: Cognitive neurosciences; UMCN 4.1: Microbial pathogenesis and host defenseAbstract
Herbal medicines are widely used by HIV patients. Several herbal medicines have been shown to interact with antiretroviral drugs, which might lead to drug failure. We have aimed to provide an overview of the modulating effects of Western and African herbal medicines on antiretroviral drug-metabolizing and transporting enzymes, focusing on potential herb-antiretroviral drug interactions. Echinacea, garlic, ginkgo, milk thistle, and St. John's wort have the potential to cause significant interactions. In vitro and in vivo animal studies also indicated other herbs with a potential for interactions; however, most evidence is based on in vitro studies. Further pharmacokinetic studies to unveil potential Western and especially African herb-antiretroviral drug interactions are urgently required, and the clinical significance of these interactions should be assessed.
This item appears in the following Collection(s)
- Academic publications [227900]
- Electronic publications [107393]
- Faculty of Medical Sciences [86236]
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