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Title: Possible drug-metabolism interactions of medicinal herbs with antiretroviral agents.
Author(s): Beukel, C.J.P. van den ; Koopmans †, P.P. ; Ven, A.J.A.M. van der ; Smet, P.A.G.M. de ; Burger, D.M.
Publication year: 2006
Source: Drug Metabolism Reviews, vol. 38, iss. 3, (2006), pp. 477-514
ISSN: 0360-2532
DOI: https://doi.org/10.1080/03602530600754065
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/49379   http://hdl.handle.net/2066/49379

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Subject: CTR 2: Clinical Pharmacology and physiology
EBP 3: Effective Primary Care and Public Health
EBP 4: Quality of Care
N4i 1: Pathogenesis and modulation of inflammation
N4i 2: Invasive mycoses and compromised host
N4i 3: Poverty-related infectious diseases
NCEBP 13: Infectious diseases and international health
NCEBP 3: Implementation Science
NCMLS 1: Infection and autoimmunity
UMCN 3.2: Cognitive neurosciences
UMCN 4.1: Microbial pathogenesis and host defense
CTR 2: Clinical Pharmacology and physiology
Organization: Internal Medicine
Clinical Pharmacy
Journal title:
Drug Metabolism Reviews
Volume: vol. 38
Issue: iss. 3
Page start: p. 477
Page end: p. 514
Abstract:
Herbal medicines are widely used by HIV patients. Several herbal medicines have been shown to interact with antiretroviral drugs, which might lead to drug failure. We have aimed to provide an overview of the modulating effects of Western and African herbal medicines on antiretroviral drug-metabolizing and transporting enzymes, focusing on potential herb-antiretroviral drug interactions. Echinacea, garlic, ginkgo, milk thistle, and St. John's wort have the potential to cause significant interactions. In vitro and in vivo animal studies also indicated other herbs with a potential for interactions; however, most evidence is based on in vitro studies. Further pharmacokinetic studies to unveil potential Western and especially African herb-antiretroviral drug interactions are urgently required, and the clinical significance of these interactions should be assessed.

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