Subject:
|
EBP 3: Effective Primary Care and Public Health IGMD 2: Molecular gastro-enterology and hepatology IGMD 9: Renal disorder N4i 1: Pathogenesis and modulation of inflammation N4i 3: Poverty-related infectious diseases N4i 4: Auto-immunity, transplantation and immunotherapy NCEBP 13: Infectious diseases and international health NCMLS 1: Immunity, infection and tissue repair NCMLS 1: Infection and autoimmunity NCMLS 5: Membrane transport and intracellular motility ONCOL 3: Translational research ONCOL 5: Aetiology, screening and detection UMCN 4.1: Microbial pathogenesis and host defense UMCN 5.1: Genetic defects of metabolism UMCN 5.4: Renal disorders |
Organization:
|
Internal Medicine Biochemistry (UMC) Gastroenterology Medical Microbiology Pharmacology-Toxicology |
Journal title:
|
American Journal of Tropical Medicine and Hygiene
|
Abstract:
|
Glutathione S-transferases (GST) are a family of enzymes involved in phase-II detoxification of endogenous and xenobiotic compounds. Polymorphisms in GST genes have been associated with susceptibility to different diseases. In this study we determined the frequencies of polymorphisms in GSTM1, GSTT1, and GSTP1 in DNA of 138 children from Cameroon, presenting with uncomplicated malaria (N = 19), malaria with minor complications (N = 81), or severe malaria (N = 38). Analyses of GSTM1 and GSTT1 were performed using PCR-multiplex procedure, while GSTP1 was done by PCR-RFLP. Subjects presenting with malaria with complications were found more often of the GSTM1-null genotype (58-64%) as compared with those with uncomplicated malaria (32%), a difference that was statistically significant. We conclude that the GSTM1-null genotype is associated with malaria with complications.
|