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Title: Short report: Severe Plasmodium falciparum malaria in Cameroon: associated with the glutathione S-transferase M1 null genotype.
Author(s): Kavishe, R.A. ; Koenderink, J.B. ; McCall, M.B.B. ; Peters, W.H.M. ; Mulder, B.; Hermsen, C.C. ; Sauerwein, R.W. ; Russel, F.G.M. ; Ven, A.J.A.M. van der
Publication year: 2006
Source: American Journal of Tropical Medicine and Hygiene, vol. 75, iss. 5, (2006), pp. 827-829
ISSN: 0002-9637
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/49315   http://hdl.handle.net/2066/49315

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Subject: EBP 3: Effective Primary Care and Public Health
IGMD 2: Molecular gastro-enterology and hepatology
IGMD 9: Renal disorder
N4i 1: Pathogenesis and modulation of inflammation
N4i 3: Poverty-related infectious diseases
N4i 4: Auto-immunity, transplantation and immunotherapy
NCEBP 13: Infectious diseases and international health
NCMLS 1: Immunity, infection and tissue repair
NCMLS 1: Infection and autoimmunity
NCMLS 5: Membrane transport and intracellular motility
ONCOL 3: Translational research
ONCOL 5: Aetiology, screening and detection
UMCN 4.1: Microbial pathogenesis and host defense
UMCN 5.1: Genetic defects of metabolism
UMCN 5.4: Renal disorders
Organization: Internal Medicine
Biochemistry (UMC)
Gastroenterology
Medical Microbiology
Pharmacology-Toxicology
Former Organization: Pharmacology/Toxicology
Journal title:
American Journal of Tropical Medicine and Hygiene
Volume: vol. 75
Issue: iss. 5
Page start: p. 827
Page end: p. 829
Abstract:
Glutathione S-transferases (GST) are a family of enzymes involved in phase-II detoxification of endogenous and xenobiotic compounds. Polymorphisms in GST genes have been associated with susceptibility to different diseases. In this study we determined the frequencies of polymorphisms in GSTM1, GSTT1, and GSTP1 in DNA of 138 children from Cameroon, presenting with uncomplicated malaria (N = 19), malaria with minor complications (N = 81), or severe malaria (N = 38). Analyses of GSTM1 and GSTT1 were performed using PCR-multiplex procedure, while GSTP1 was done by PCR-RFLP. Subjects presenting with malaria with complications were found more often of the GSTM1-null genotype (58-64%) as compared with those with uncomplicated malaria (32%), a difference that was statistically significant. We conclude that the GSTM1-null genotype is associated with malaria with complications.

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