Severe encephalopathy after high-dose chemotherapy with autologous stem cell support for brain tumours.

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Publication year
2006Source
Anticancer Research, 26, 1B, (2006), pp. 729-33ISSN
Publication type
Article / Letter to editor

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Organization
Medical Oncology
Paediatrics - OUD tm 2017
Journal title
Anticancer Research
Volume
vol. 26
Issue
iss. 1B
Page start
p. 729
Page end
p. 33
Subject
NCMLS 2: Immune Regulation; ONCOL 1: Hereditary cancer and cancer-related syndromes; ONCOL 3: Translational research; UMCN 1.1: Functional Imaging; UMCN 1.4: Immunotherapy, gene therapy and transplantationAbstract
Recurrent medulloblastoma carries a poor prognosis. Long-term survival has been obtained with high-dose chemotherapy with autologous stem cell transplantation and secondary irradiation. A 21-year-old woman with recurrent medulloblastoma after previous chemotherapy and radiotherapy is presented. The patient was treated with high-dose chemotherapy and autologous stem cell transplantation. She developed a severe treatment-related encephalopathy which affected her quality of life and neurocognitive functioning for the rest of her life. Possible causative factors are discussed and central nervous system toxicity by high-dose chemotherapy in brain tumour patients is reviewed. Case reports on severe central nervous system toxicity have been reported, but data from prospective studies on neurocognitive functioning are not available. These data strongly support a systematic long-term follow-up of brain tumour patients treated with high-dose chemotherapy with emphasis on neurocognitive function tests.
This item appears in the following Collection(s)
- Academic publications [227881]
- Electronic publications [107344]
- Faculty of Medical Sciences [86219]
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