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Publication year
2006Source
European Journal of Surgical Oncology, 32, 3, (2006), pp. 253-258ISSN
Publication type
Article / Letter to editor

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Organization
Surgery
Journal title
European Journal of Surgical Oncology
Volume
vol. 32
Issue
iss. 3
Page start
p. 253
Page end
p. 258
Subject
UMCN 1.5: Interventional oncologyAbstract
AIMS: Presently, in Europe the treatment of node-negative colorectal cancer (CRC) patients consists of surgical resection of the primary tumour without adjuvant systemic therapy. However, up to 30% of these patients will develop disease recurrence. These high-risk patients are possibly identified by occult tumour cell (OTC) assessment in lymph nodes. In this paper, studies on the clinical relevance of OTC in lymph nodes are reviewed. METHODS: A literature search was conducted in the National Library of Medicine by using the keywords colonic, rectal, colorectal, neoplasm, adenocarcinoma, cancer, lymph node, polymerase chain reaction, mRNA, immunohistochemistry, micrometastases and isolated tumour cells. Additional articles were identified by cross-referencing from papers retrieved in the initial search. RESULTS: The upstaging percentages through OTC assessment and the prognostic relevance of OTC in lymph nodes vary among studies, which is related to differences in techniques used to detect OTC. CONCLUSIONS: We conclude that OTC examination techniques should be standardized to illuminate whether OTC in lymph nodes can reliably identify high-risk node-negative patients.
This item appears in the following Collection(s)
- Academic publications [204887]
- Electronic publications [103214]
- Faculty of Medical Sciences [81046]
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