Subject:
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EBP 3: Effective Primary Care and Public Health N4i 2: Invasive mycoses and compromised host N4i 3: Poverty-related infectious diseases NCEBP 13: Infectious diseases and international health UMCN 3.2: Cognitive neurosciences UMCN 4.1: Microbial pathogenesis and host defense |
Organization:
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Clinical Pharmacy Internal Medicine |
Abstract:
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We studied the pharmacokinetics of lopinavir/ritonavir dosed at 800/200 mg a day in 20 HIV-1-infected patients, and evaluated the effect of dose modifications in the case of trough concentration (Ctrough) levels less than 1.0 mg/l. Ctrough levels after the daily administration of lopinavir/ritonavir were lower than with twice daily administration. Dose modifications in four patients with Ctrough levels less than 1.0 mg/l succeeded in only one patient. Therapeutic drug monitoring can identify patients with lower-than-expected lopinavir exposure in a larger study.
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