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Title: Pharmacokinetics of once-daily lopinavir/ritonavir and the influence of dose modifications.
Author(s): Porte, C.J.L. la ; Schippers, E.F.; Ende, M.E. van der; Koopmans †, P.P. ; Blok, W.L. ; Kauffmann, R.H.; Kroon, F.P.; Burger, D.M.
Publication year: 2005
Source: Aids, vol. 19, iss. 10, (2005), pp. 1105-1107
ISSN: 0269-9370
DOI: https://doi.org/10.1097/01.aids.0000174459.93744.4a
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/49125   http://hdl.handle.net/2066/49125

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Subject: EBP 3: Effective Primary Care and Public Health
N4i 2: Invasive mycoses and compromised host
N4i 3: Poverty-related infectious diseases
NCEBP 13: Infectious diseases and international health
UMCN 3.2: Cognitive neurosciences
UMCN 4.1: Microbial pathogenesis and host defense
Organization: Clinical Pharmacy
Internal Medicine
Journal title:
Aids
Volume: vol. 19
Issue: iss. 10
Page start: p. 1105
Page end: p. 1107
Abstract:
We studied the pharmacokinetics of lopinavir/ritonavir dosed at 800/200 mg a day in 20 HIV-1-infected patients, and evaluated the effect of dose modifications in the case of trough concentration (Ctrough) levels less than 1.0 mg/l. Ctrough levels after the daily administration of lopinavir/ritonavir were lower than with twice daily administration. Dose modifications in four patients with Ctrough levels less than 1.0 mg/l succeeded in only one patient. Therapeutic drug monitoring can identify patients with lower-than-expected lopinavir exposure in a larger study.

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