Preserved contribution of nitric oxide to baseline vascular tone in deconditioned human skeletal muscle.

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Publication year
2005Source
Journal of Physiology, 565, Pt 2, (2005), pp. 685-694ISSN
Publication type
Article / Letter to editor

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Organization
Physiology
Internal Medicine
Pharmacology-Toxicology
Former Organization
Pharmacology/Toxicology
Journal title
Journal of Physiology
Volume
vol. 565
Issue
iss. Pt 2
Page start
p. 685
Page end
p. 694
Subject
IGMD 5: Health aging / healthy living; NCEBP 14: Cardiovascular diseases; UMCN 2.2: Vascular medicine and diabetes; UMCN 5.4: Renal disordersAbstract
Deconditioning is a risk factor for cardiovascular disease. Exercise reduces this risk, possibly by improving the vascular endothelial nitric oxide (NO) pathway. The effect of deconditioning on the NO pathway is largely unknown. This study was designed to assess baseline NO availability in the leg vascular bed after extreme, long-term deconditioning (spinal cord-injured individuals, SCI) as well as after moderate, short-term deconditioning (4 weeks of unilateral lower limb suspension, ULLS). For this purpose, seven SCI were compared with seven matched controls. Additionally, seven healthy subjects were studied pre- and post-ULLS. Leg blood flow was measured by venous occlusion plethysmography at baseline and during infusion of 5 incremental dosages of N(G)-monomethyl-L-arginine (L-NMMA) into the femoral artery. Sodium nitroprusside (SNP) was infused to test vascular responsiveness to NO. Baseline leg vascular resistance tended to be higher in SCI compared with controls (37+/-4 versus 31+/-2 arbitrary units (AU), P=0.06). Deconditioning altered neither the vasoconstrictor response to L-NMMA (increase in resistance in SCI versus controls: 102+/-33% versus 69+/-9%; pre- versus post-ULLS: 95+/-18% versus 119+/-15%), nor the vascular responsiveness to NO. In conclusion, two human in vivo models of deconditioning show a preserved baseline NO availability in the leg skeletal muscle vascular bed.
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- Academic publications [202828]
- Electronic publications [100988]
- Faculty of Medical Sciences [80037]
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