Publication year
2005Source
Expert Review of Vaccines, 4, 5, (2005), pp. 699-710ISSN
Publication type
Article / Letter to editor

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Organization
Tumorimmunology
Surgery
Journal title
Expert Review of Vaccines
Volume
vol. 4
Issue
iss. 5
Page start
p. 699
Page end
p. 710
Subject
N4i 1: Pathogenesis and modulation of inflammation; NCMLS 1: Immunity, infection and tissue repair; NCMLS 2: Immune Regulation; ONCOL 3: Translational research; UMCN 1.4: Immunotherapy, gene therapy and transplantationAbstract
Dendritic cells are the most potent antigen-presenting cells of the immune system and represent a promising tool in therapeutic vaccination against cancer. Immunotherapy applying ex vivo-generated and tumor antigen-loaded dentritic cells has been successfully introduced in clinical vaccination protocols and has proven to be feasible and effective in some patients. A better understanding of how dentritic cells succeed to induce and modulate immunity is necessary to optimally exploit dentritic cells in anticancer vaccines. The authors will review novel insights in antigen loading, activation and migration of dentritic cells and their impact on the application of ex vivo-generated dentritic cell vaccines. In addition, novel means to exploit dentritic cells in cancer vaccines by loading and activation of dentritic cells directly in situ and possible obstacles that should be overcome to induce long-lasting immunity in therapeutic settings will be discussed.
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- Academic publications [232047]
- Faculty of Medical Sciences [89033]
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