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Publication year
2005Source
American Journal of Physiology : Heart and Circulatory Physiology, 288, 4, (2005), pp. H1747-55ISSN
Publication type
Article / Letter to editor

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Organization
Physiology
Internal Medicine
Pharmacology-Toxicology
Former Organization
Pharmacology/Toxicology
Journal title
American Journal of Physiology : Heart and Circulatory Physiology
Volume
vol. 288
Issue
iss. 4
Page start
p. H1747
Page end
p. 55
Subject
IGMD 5: Health aging / healthy living; NCEBP 14: Cardiovascular diseases; UMCN 2.2: Vascular medicine and diabetes; UMCN 5.4: Renal disordersAbstract
Physical inactivity or deconditioning is an independent risk factor for atherosclerosis and cardiovascular disease. In contrast to exercise, the vascular changes that occur as a result of deconditioning have not been characterized. We used 4 wk of unilateral lower limb suspension (ULLS) to study arterial and venous adaptations to deconditioning. In contrast to previous studies, this model is not confounded by denervation or microgravity. Seven healthy subjects participated in the study. Arterial and venous characteristics of the legs were assessed by echo Doppler ultrasound and venous occlusion plethysmography. The diameter of the common and superficial femoral artery decreased by 12% after 4 wk of ULLS. Baseline calf blood flow, as measured by plethysmography, decreased from 2.1 +/- 0.2 to 1.6 +/- 0.2 ml.min(-1).dl tissue(-1). Both arterial diameter and calf blood flow returned to baseline values after 4 wk of recovery. There was no indication of a decrease in flow-mediated dilation of the superficial femoral artery after ULLS deconditioning. This means that functional adaptations to inactivity are not simply the inverse of adaptations to exercise. The venous pressure-volume curve is shifted downward after ULLS, without any effect on compliance. In conclusion, deconditioning by 4 wk of ULLS causes significant changes in both the arterial and the venous system.
This item appears in the following Collection(s)
- Academic publications [229097]
- Electronic publications [111477]
- Faculty of Medical Sciences [87745]
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