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Publication year
2005Source
Science, 310, 5747, (2005), pp. 490-3ISSN
Publication type
Article / Letter to editor

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Organization
Physiology
Journal title
Science
Volume
vol. 310
Issue
iss. 5747
Page start
p. 490
Page end
p. 3
Subject
IGMD 9: Renal disorder; NCMLS 5: Membrane transport and intracellular motility; UMCN 5.4: Renal disordersAbstract
Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides.
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- Academic publications [229134]
- Electronic publications [111496]
- Faculty of Medical Sciences [87758]
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