Stress and outcome success in IVF: the role of self-reports and endocrine variables.
SourceHuman Reproduction, 20, 4, (2005), pp. 991-996
Article / Letter to editor
Display more detailsDisplay less details
SW OZ BSI KLP
Epidemiology, Biostatistics & HTA
SubjectEBP 1: Determinants of Health and Disease; EBP 2: Effective Hospital Care; IGMD 6: Hormonal regulation; NCEBP 12: Human Reproduction; NCEBP 8: Psychological determinants of chronic illness; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection; UMCN 5.2: Endocrinology and reproduction; EBP 1: Determinants of Health and Disease; EBP 2: Effective Hospital Care
BACKGROUND: The aim of this study was to examine the associations between urinary levels of the stress hormones adrenaline, noradrenaline and cortisol during treatment with self reported stress, in order to investigate the mechanism for the previously observed negative association of anxiety and depression with the outcome of IVF/ICSI. METHODS: In a multicentre prospective cohort study, women entering their first cycle of IVF/ICSI treatment were asked to participate. From each participant nocturnal urine samples were collected; pre-treatment, before oocyte retrieval and before embryo-transfer (ET), to assess hormonal concentrations. Additionally, two questionnaires were administered before the start of the treatment to measure anxiety and depression. RESULTS: 168 women completed the questionnaires and collected at least two urine specimens. A significant positive correlation between urinary adrenaline concentrations at baseline and ET and the scores on depression at baseline were found. In women with successful treatment, lower concentrations of adrenaline at oocyte retrieval and lower concentrations of adrenaline and noradrenaline at ET, compared with unsuccessful women, were found. CONCLUSIONS: The significant positive association of adrenaline concentration with pregnancy and with depression suggested that this adrenal hormone could be one of the links in the complex relationship between psychosocial stress and outcome after IVF/ICSI.
Upload full text
Use your RU credentials (u/z-number and password) tolog in with SURFconextto upload a file for processing by the repository team.